I know that a lot of what Nix does is working around its break from FHS, but I can imagine there are still things that seep through. Are there any unsolvable problems due to this?
I saw on this post that it is possible to use FHS on Nix. Does this solve all potential issues then?
You may be interested in reading this post about the process of packaging Steam.
tl;dr: It's mostly an annoyance reserved for packagers to deal with. Dynamically linked executables can be patched in a fairly universal fashion to work without FHS, so that's the go-to approach. If the executable is statically linked, the package may have to ship a source patch instead. If the executable is statically linked & close-source, the packagers are forced to resort to simulating an FHS environment via chroot.
So that means packaging software for nix is a pain, compared to, say, gentoo or arch's AUR, but only for a small subset of packages.
I'll keep this in mind as I'm exploring if I should switch from Gentoo.
Gobolinux enters the room.
Gobo's been around and doing its alternative thing, successfully, for 20 years, so no. It's not a problem.