There's a whole bunch of different approaches.

Buddhism suggests eliminating the Self (or recognising it as a set of contingent parts and using that to de-experientialise it.)

Catholicism suggests you recognise the self as an emanation of a divine Logos and that you can reunify with it because at heart there's no separation in the first place and you need to get over yourself.

Transhumanism (or at least Socialist transhumanism) just says "Fuck it, work the damn problem." Make humans immortal, unable to suffer, go do a space eventually when you feel like it, and eventually point us in the direction of preventing the heat death of the universe by collapsing the false vacuum and creating a noosphere at the omega point. You might not get there, but other people will

You'll note that all of these map onto sections of Matt's "what to do after-FALGSC" rambles.