I'll go first. Mine is the instant knockout drug. Like Dexter's intramuscular injection that causes someone to immediately lose consciousness. Or in the movie Split where there's the aerosol spray in your face that makes you instantly unconscious. Or pretty much any time someone uses chloroform.
When you do this, what do people say? Do they say "Open it!" or do they ever tell you what it is?
What is the point of wrapping the gift if you're just going to tell the person what's inside?
I don't like the expectations around gifts in my culture, I don't like surprises, i despise consumerism, I am a minimalist, and I don't like gifts being wrapped. My friends know this.
Usually my response when someone hands me a wrapped gift is to frown and ask what it is and why they got it for me. The feeling is usually "damn it. How many wage slaves suffered for this thing?" And "ugh, now I have something else that I have to lug around and figure out how to find it a new home where it won't end up in a landfill"
If they want to give me something nice (eg cook me dinner or hand me a flower), its appreciated. But not on some strange cultural expectation or wrapped in a dead tree or uncompostable plastic single use trash.