While I agree with killing bugs that harm people, there's a caveat for smashing in particular. Smashing a biting kissing bug will just rub all of its guts and likely Chagas infested feces into the bite. It probably applies to a number of other biting bugs to varying extents depending on how they might spread disease, but kissing bugs and Chagas are the examples I know. Really, I just really think everyone should be aware of Chagas disease and am using this thread as an excuse to mention it.
They're like assassin bugs that go for mammal blood.