Eclipse Phase draws heavily on Takeshi Kovacs. It differs in being explicitly pro-trans and directly discussing how transhumanism and specifically the ability to change bodies or drasticly re-work your existing body resulted in a great deal of gender liberation. But it's a horror setting, so the psychological shock of being sleeved in to a body that doesn't fit your self-identity, or for some people the experience of sleeving in a cybernetic or entirely machine body, can be extremely distressing with serious psychological consequences. It's the only game or sci-fi setting I've ever heard of where a standard combat action is doing time-accelerated therapy with your ai psychologist so you can cope with the horrific thing you just witnessed and get back in to the firefight instead of going in to shock.