I feel like they'd be more convenient for me because I am so forgetful that it's now been over a month since I've taken my HRT, and my prescription lapsed with 5 months worth of refills remaining.
What should I be aware of, other than the cost difference?
They fall off at the slightest provocation. Sweat, showering, bathing... You're lucky if the damn thing stays on afterwards.
If you slap a couple of 3M Tegaderm dressings over it (minimum of two of the 2 3/8" x 2 3/4" ones, P/N 1624W, available in bulk via Amazon), it will stay put, but the Tegaderm dressings may start to roll up around the edges a bit. Once they start getting lint in them, it's a race until you're due for your next patch to see if everything stays in place until then.
You also can't do monotherapy with the Climara patches; the dose isn't high enough, even with the 25 cm2/7.6 mg ones. Bica works pretty well with them.
Skin irritation is also a possible concern.
Edit: My regimen for getting the best patch+dressing adhesion is as follows:
I'm probably doing it wrong.
Also, they're more effective than oral estradiol on account of the estradiol not getting metabolized in your liver. But it suuuuucks when you ruin a 1-week patch on day 3 and have to slap on the next week's. Keep gel as a backup -- the homebrew stuff from Otokonoko is supposed to be really good and fast-drying, but I haven't tried it yet.