from this sub: https://old.reddit.com/r/TherapeuticKetamine/comments/v4jz1p/weizmann_institute_of_science_ketamine_is_now/
study: https://www.cell.com/neuron/fulltext/S0896-6273(22)00409-3
The Kcnq2 gene encodes for the Kv7.2 protein, a slow-acting, voltage-gated potassium channel that plays a critical role in the regulation of neuronal excitability
glutamatergic drugs VS old anti-depressants which focus on short term neurotransmitters
The researchers then tested ketamine’s effects in combination with an epilepsy drug, retigabine, known to activate potassium channels in the brain. When the drugs were given together, ketamine’s antidepressant effects were significantly enhanced.
an anesthetic and anti-epileptic, chill ass regimen
By revealing a new mechanism of ketamine’s action, the study may make it possible to expand the use ketamine-based drugs. This, in turn, might help these drugs fully deliver on their promise of providing new hope for depression.
boomer millennials: "in my day, we had to treat our depression with a drug that forced you to reckon with ego death and jump down into the timeless abyss from which all existence was generated"
I think I'm in the same boat, I've done ketamine and other disso's and the relief feels very temporary. Mushrooms seem far better but I have a much harder time on mushrooms trips than pretty much anything else. I've been thinking about doing mushrooms more regularly and just telling myself that the difficulty with the trip is part of some kind of shamanistic purge because I could really use the relief and I've not had the best time with anti depressants.
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