the human body will encounter complications in low and zero gravity
ftl will never happen
space stations are a scam that rich tech ceo's promise
mars cannot be terraformed
life is probably unexceptional and we will never make contact with others
you will all die on earth
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That and "It doesn't matter if we suck Earths resourses dry and leave it a husk, because we'll just move on to the next one!"
Notice all the video game sci-fi settings are depressing capitalist hellscapes.